|
Zollinger-Ellison syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The local levels of cytokine mRNA in patients with both diseases exceeded the levels in patients with H. pylori only (IL-6, p < 0.05; IL-8, p < 0.05) and ZES only (IL-6, p < 0.05; tumor necrosis factor-a, p < 0.05).
|
11866267 |
2002 |
|
Zika Virus Infection
|
0.050 |
Biomarker
|
disease |
BEFREE |
We found that gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) T cell responses to NS3 differentiated DENV and ZIKV infections with 94% sensitivity and 92% specificity.
|
30087165 |
2018 |
|
Zika Virus Infection
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels.
|
29771234 |
2018 |
|
Zika Virus Infection
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
TNF-α upregulation, microgliosis and upregulation of complement system proteins, C1q and C3, are induced by ZIKV infection.
|
31488835 |
2019 |
|
Zika Virus Infection
|
0.050 |
Biomarker
|
disease |
BEFREE |
We show that disruption of apical tight junctions by proinflammatory cytokine tumor necrosis factor alpha (TNF-α) sensitizes 3-D-cultured BBB cells to ZIKV infection and that 3-D derived BBB cells can be used to model the transmigration of ZIKV-infected monocytes across the endothelial barrier to access underlying astrocytes.
|
28656176 |
2019 |
|
Zika Virus Infection
|
0.050 |
Biomarker
|
disease |
BEFREE |
Altogether, the results show that neonatal ZIKV infection has long-term neuropathological and behavioral complications in mice and suggest that early inhibition of TNF-α-mediated neuroinflammation might be an effective therapeutic strategy to prevent the development of chronic neurological abnormalities.
|
29875203 |
2018 |
|
Yersinia infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Tissue levels of IL-10, as well as the inflammatory cytokines TNF-alpha, IL-6, and gamma interferon and the chemokine macrophage chemotactic protein 1, are similar in TLR2(+/+) and TLR2(-/-) mice during enteropathogenic Yersinia infection.
|
17420232 |
2007 |
|
Xanthomatosis, Cerebrotendinous
|
0.010 |
Biomarker
|
disease |
BEFREE |
LJP could also restore the levels of serum cytokines interleukin (IL-2), tumor necrosis factor (TNF-α) and Interferon-γ (IFN-γ) in the CTX-treated mice.
|
30296293 |
2018 |
|
X-linked agammaglobulinemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Herein, we measured TLR-4 and TLR-9 RNA levels and consequently TNF-α and IFN-α production in peripheral blood mononuclear cells (PBMCs) of patients with CVID and XLA.
|
30698158 |
2018 |
|
X-linked agammaglobulinemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To clarify the pathogenesis of CVID and IgAD of Japanese patients, we investigated the mutations of TNF family members TACI, APRIL, B-cell activating factor (BAFF), B-cell maturation antigen (BCMA) and BAFF receptor (BAFF-R) genes and the expression levels of BAFF and APRIL in patients with CVID, IgAD and X-linked agammaglobulinaemia (XLA).
|
18204790 |
2008 |
|
Wheezing
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Serum levels of Tumor Necrosis Factor-α (TNF-α), Monocyte chemotactic protein-1 (MCP-1), Vascular endothelial growth factor (VEGF), Epidermal growth factor (EGF), forced expiratory volume-one second (FEV<sub>1</sub>) and respiratory symptoms including; Chest wheeze (CW), night wheeze (NW), night cough (NC) and cough and wheeze during exercise (ECW) were assessed at the baseline (step 0), one and two months after starting treatment (step I and II, respectively).
|
30961947 |
2019 |
|
Wheezing
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
Children with TNF-308 GG had decreased risk of asthma (odds ratio, 0.8; 95% confidence interval, 0.7-0.9) and lifetime wheezing (odds ratio, 0.8; 95% confidence interval, 0.7-0.9).
|
16456144 |
2006 |
|
Wheezing
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
We can conclude that genetic variation in TNF-α-308G/A may contribute to childhood asthma and wheezing.
|
23376082 |
2013 |
|
Wheezing
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
Home dampness is a risk factor for asthma and wheeze among children, especially for those with the TNF-308 A allele.
|
21307151 |
2011 |
|
Wheezing
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
In girls, the OR for the TNFA-308A allele and wheeze in the last 12 months was 3.6 (P = 0.01) and for current asthma it was 6.0 (P = 0.0006).
|
15137526 |
2004 |
|
Wheezing
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, respectively.
|
24465030 |
2014 |
|
Wheezing
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Haplotype analysis showed that TNF-alpha-308G, LT-alpha+252A/TNF-alpha-308A, LT-alpha+252A was associated with a markedly increased risk for both asthma and infant wheezing.
|
16204594 |
2005 |
|
Wheezing
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
For example, the odds ratio (OR) for developing early wheeze related to early maternal smoking was 2.4 [95% confidence interval (CI) 1.6-3.7] in children with a wild-type CC homozygote genotype of the TNF-857 SNP, while no tobacco-related risk was seen in children carrying the rare T allele.
|
20210814 |
2010 |
|
Wheezing
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
For three polymorphisms: CYP1A1*2A, CYP1A1*2B, and TNF -308 there was a pattern consistent with interaction between genotype and TDI exposure status for the majority of symptoms investigated, although it did reach statistical significance only for some symptoms: among TDI-exposed workers, the CYP1A1 variant carriers had increased risk (CYP1A1*2A and eye symptoms: variant carriers OR 2.0 95% CI 0.68-6.1, p-value for interaction 0.048; CYP1A1*2B and wheeze: IV carriers OR = 12, 1.4-110, p-value for interaction 0.057).
|
18447907 |
2008 |
|
Wet age-related macular degeneration
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate tumor necrosis factor-α gene polymorphisms in unrelated Taiwan Chinese patients with wet age-related macular degeneration (AMD) and controls.
|
21060270 |
2011 |
|
West Nile viral infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
To test the biological significance of TNF-alpha against WNV in vivo, experiments were performed with TNF receptor-1 (TNF-R1)-deficient and TNF-alpha-depleted C57BL/6 mice.
|
18632856 |
2008 |
|
West Nile Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor alpha protects against lethal West Nile virus infection by promoting trafficking of mononuclear leukocytes into the central nervous system.
|
18632856 |
2008 |
|
Well Differentiated Oligodendroglioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tumor necrosis factor modulates transcription of myelin basic protein gene through nuclear factor kappa B in a human oligodendroglioma cell line.
|
12175864 |
2002 |
|
Weight Gain
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Genetic association between TNF-alpha -308 G>A polymorphism and longitudinal weight change during clozapine treatment.
|
20521320 |
2010 |
|
Wasting Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF)-cachectin increases the expression of the human immunodeficiency virus (HIV), reverses the therapeutic efficacy of zidovudine (ZDV), and may contribute to the wasting syndrome.
|
8099612 |
1993 |